Article Title

Identification of a sildenafil analogue adulterated in two herbal food supplements


Consumption of herbal supplements becomes more and more popular in the world. For the sake of public health, enhanced supervision on those products is needed. A novel sildenafil analogue is detected from two herbal dietary supplements in our laboratory. Its structure has been identified by various NMR techniques, mass spectrum, IR and X-ray diffraction. This compound is slightly different from sildenafil (Viagra) in the piperazine moiety, where N-methyl group in sildenafil is replaced by N-hydroxy-ethyl group. Thereby this compound is named as hydroxyhomosildenafil. Noticeably, this compound has not been approved as medication. Therefore, it is necessary to monitor diverse analogues besides the commercial chemical compounds.

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