Anti-neuroinflammatorypolyketides from the medicinal herb-derived fungal strain Didymocyrtis brachylaenae Km1530

Authors

Chia-Hao Chang, Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
Yun-Rong Zhang, Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
Shu-Jung Huang, Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
George Hsiao, Department of Pharmacology, School of Medicine, Taipei Medical University, Taipei 11031, Taiwan
Wei-Chiung Chi, Department of Food Science, National Quemoy University, Kinmen 89250, Taiwan
Andrea Gu, Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
Yu-Wei Lai, Center of General Education, National Taipei University, New Taipei 273303, Taiwan
Tzong-Huei Lee, Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, TaiwanFollow

Keywords

Anti-neuroinflammation, Brachylactone, Didymocyrtis brachylaenae, Nitric oxide, Polyketide

Abstract

A series of chromatographic separation on the liquid-state fermented products of Didymocyrtis brachylaenae Km1530 derived from the littoral medicinal herb Atriplex maximowicziana Makino, resulted in the isolation of compounds 1—13. Their structures were determined by spectroscopic analysis as fivepreviously unreported C13 polyketides, namely brachylactones A—D (1—4) and brachic acid (5), along with eight known compounds 6—13. Among these, brachy-lactones A (1) and B (2) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-induced murine BV- 2 microglial cells at a concentration of 20 μM without any cytotoxicity.

Abstract Image

Recommended Citation

Chang, Chia-Hao; Zhang, Yun-Rong; Huang, Shu-Jung; Hsiao, George; Chi, Wei-Chiung; Gu, Andrea; Lai, Yu-Wei; and Lee, Tzong-Huei (2025) "Anti-neuroinflammatorypolyketides from the medicinal herb-derived fungal strain Didymocyrtis brachylaenae Km1530," Journal of Food and Drug Analysis: Vol. 33 : Iss. 3 , Article 9.
Available at: https://doi.org/10.38212/2224-6614.3560

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