Keywords
Antioxidant, GABA receptors, Neuroprotection, Oxidative stress, Sleep
Abstract
Jujube seed extract (JSE), rich in polyphenols and flavonoids, exhibits neuroprotective and sleep-enhancing properties.In vitro, JSE protected HT22 cells against oxidative stress by activating the Nrf2/HO-1 pathway and upregulatingantioxidant enzymes. In vivo, JSE increased non-REM sleep and delta wave activity in pentobarbital- and caffeine-induced sleep models. Spinosin contributed to these effects. Long-term JSE administration upregulated GABAA, GABAB, and 5-HT1A receptors in brain tissue. These findings suggest that JSE offers dual benefits in mitigating oxidativestress and promoting sleep through antioxidant defense and neurotransmitter modulation, supporting its potential as a natural therapeutic agent.
Recommended Citation
Chung, Seok Hyun; Kim, Hyeongyeong; Kim, Singeun; Jeong, Pan-Young; and Lee, Hyowon
(2025)
"Protective effects of jujube seed extract against oxidative stress in HT22 cells and its sleep-promotingaction through GABAergic receptors,"
Journal of Food and Drug Analysis: Vol. 33
:
Iss.
3
, Article 8.
Available at: https://doi.org/10.38212/2224-6614.3555
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