Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain undetermined. In this study, we showed the treatment of RSV upregulated StAR expression in human granulosa cells. G protein-coupled estrogen receptor (GPER) and ERK1/2 signaling were involved in RSV-stimulated StAR expression and P4 production. In addition, the expression of a transcriptional repressor, Snail, was downregulated by RSV, which contributed to the RSV-induced induction of StAR expression and P4 production.
Song, Tinglin; Chen, Jiaye; Yang, Sizhu; Liu, Boqun; Zhang, Lingling; Zhang, Qian; Cheng, Jung-Chien; and Fang, Lanlan
"Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells,"
Journal of Food and Drug Analysis: Vol. 31
, Article 9.
Available at: https://doi.org/10.38212/2224-6614.3460
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