Systems pharmacology dissection of the mechanisms and therapeutic potential of Cassiae semen for hepatoprotection and brightening eyes

Authors

Jing-Xiao Zhang, School of Food and Drug, Luoyang Normal University, China
Zi-Yi Chen, Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen University, China
Xue-Zhen Huang, School of Food and Drug, Luoyang Normal University, China
Lin-Yue Qi, School of Food and Drug, Luoyang Normal University, China
Wei Zhou, Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen University, ChinaFollow

Abstract

Cassiae semen has been shown to play significant roles in reversing “liver fire” to improve vision. The systems mechanism of Cassiae semen for hepatoprotection and brightening eyes has not been fully explored. The systems pharmacology approach is proposed to dissect the potential pharmacological mechanism of Cassiae semen for hepatoprotection and brightening eyes. The results showed that 26 active components of Cassiae semen that connected with 230 targets were obtained. Gene ontology enrichment, network and pathway analysis explored that Cassiae semen is responsible for hepatoprotection and brightening eyes. The current study will contribute to the research and development of functional foods.

Abstract Image

Recommended Citation

Zhang, Jing-Xiao; Chen, Zi-Yi; Huang, Xue-Zhen; Qi, Lin-Yue; and Zhou, Wei (2022) "Systems pharmacology dissection of the mechanisms and therapeutic potential of Cassiae semen for hepatoprotection and brightening eyes," Journal of Food and Drug Analysis: Vol. 30 : Iss. 3 , Article 7.
Available at: https://doi.org/10.38212/2224-6614.3417

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