Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Authors

M.-C. Chen
G.-J. Wang
Y.-H. Kuo
Y.-R. Chiang
T.-Y. Cho
Y.-M. Ju
T.-H. Lee

Abstract

Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with Emax values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production. © 2018

Abstract Image

ScienceDirect Link

10.1016/j.jfda.2018.05.007

Recommended Citation

Chen, M.-C.; Wang, G.-J.; Kuo, Y.-H.; Chiang, Y.-R.; Cho, T.-Y.; Ju, Y.-M.; and Lee, T.-H. (2019) "Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata," Journal of Food and Drug Analysis: Vol. 27 : Iss. 1 , Article 32.
Available at: https://doi.org/10.1016/j.jfda.2018.05.007

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Fulltext URL

https://www.sciencedirect.com/science/article/pii/S1021949818300887/pdfft?md5=1c32af5889c152b06fc719c1392c11f6&pid=1-s2.0-S1021949818300887-main.pdf