Article Title

Hypocholesterolemic activity of indigenous probiotic isolate Saccharomyces cerevisiae ARDMC1 in a rat model

Authors

D. Saikia
A.K. Manhar
B. Deka
R. Roy
K. Gupta
N.D. Namsa
P. Chattopadhyay
R. Doley
M. Mandal

Abstract

The aim of this study was to investigate probiotic attributes of Saccharomyces cerevisiae ARDMC1 isolated from traditional rice beer starter cake and its hypocholesterolemic effects on Wistar rats fed a high-cholesterol diet. The indigenous isolate ARDMC1 showed potential probiotic characteristics such as tolerance to simulated gastrointestinal stress conditions, autoaggregation properties, and adhesion to intestinal epithelium Caco-2 cell line. In addition, ARDMC1 isolate exhibited in vitro cholesterol assimilation properties in media supplemented with cholesterol. Furthermore, administration of probiotic isolate to rats fed a hypercholesterolemic diet resulted in significant reduction of serum total cholesterol, low-density lipoprotein cholesterol, and triglyceride at the end of 42 days. The present study envisages ARDMC1 as a promising starter culture for the preparation of functional foods with properties to combat cardiovascular diseases. © 2017

Abstract Image

ScienceDirect Link

10.1016/j.jfda.2016.12.017

Recommended Citation

Saikia, D.; Manhar, A.K.; Deka, B.; Roy, R.; Gupta, K.; Namsa, N.D.; Chattopadhyay, P.; Doley, R.; and Mandal, M. (2018) "Hypocholesterolemic activity of indigenous probiotic isolate Saccharomyces cerevisiae ARDMC1 in a rat model," Journal of Food and Drug Analysis: Vol. 26 : Iss. 1 , Article 38.
Available at: https://doi.org/10.1016/j.jfda.2016.12.017

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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.