Abstract
In this study, linear relationships between response and concentration were used to estimate the detection limit (DL) and quantification limit (QL) for five avermectins: Emamectin, abamectin, doramectin, moxidectin, and ivermectin. Estimation of DL and QL was based on the standard deviation of residual and y-intercept of the regression line at low concentrations of avermectins, using the dispersive solid-phase extraction procedure. Avermectin extracts were analyzed using liquid chromatography tandem mass spectrometry. Based on the regression slope, DL and QL were higher at concentrations of 0.3-0.4 μg/kg and 1 μg/kg, respectively, for all avermectin compounds. Linearity assessment was performed by linear regression, which incorporated a regression model, outlier rejection, and evaluation of the assumption with a significant test. For all avermectins, there is a significant correlation between response and concentration in the range 1-15 μg/kg, and the y-intercept passes through origin (zero). © 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.
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Recommended Citation
Ismail, R.; Lee, H.Y.; Mahyudin, N.A.; and Abu, Bakar F.
(2014)
"Linearity study on detection and quantification limits for the determination of avermectins using linear regression,"
Journal of Food and Drug Analysis: Vol. 22
:
Iss.
4
, Article 11.
Available at: https://doi.org/10.1016/j.jfda.2014.01.026
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