The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against -anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters. Copyright © 2013, Food and Drug Administration, Taiwan.
Banerjee, S.; Chattopadhyay, P.; Ghosh, A.; Bhattacharya, S.S.; Kundu, A.; and Veer, V.
"Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin a poisoning,"
Journal of Food and Drug Analysis: Vol. 22
, Article 13.
Available at: https://doi.org/10.1016/j.jfda.2014.01.022
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