Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin a poisoning

Authors

S. Banerjee
P. Chattopadhyay
A. Ghosh
S.S. Bhattacharya
A. Kundu
V. Veer

Abstract

The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against -anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters. Copyright © 2013, Food and Drug Administration, Taiwan.

ScienceDirect Link

10.1016/j.jfda.2014.01.022

Recommended Citation

Banerjee, S.; Chattopadhyay, P.; Ghosh, A.; Bhattacharya, S.S.; Kundu, A.; and Veer, V. (2014) "Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin a poisoning," Journal of Food and Drug Analysis: Vol. 22 : Iss. 2 , Article 13.
Available at: https://doi.org/10.1016/j.jfda.2014.01.022

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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Fulltext URL

https://www.sciencedirect.com/science/article/pii/S1021949814000234/pdfft?md5=dbd8b1cfa1fe02f222ab5a30b9f9c28a&pid=1-s2.0-S1021949814000234-main.pdf