Living organisms have evolved ubiquitous mechanisms to manage a vast multitude of stressors and noxious conditions. Although Nrf2 mainly plays a major role in cellular antioxidant defence, results from recent studies have highlighted its ubiquitous roles in cellular cytoprotection including anti-inflammatory function. As oxidative stress and inflammatory tissue damage are two major culprits in the pathogenesis of the majority of malignancies and other disorders, Nrf2 is recognized as a potential preventive target. Some chemoprotective and chemopreventive phytochemicals are capable of activating Nrf2 signaling, thereby fortifying cellular defence capacity.
"Nrf2, an essential component of cellular stress response, as a potential target of hormetic phytochemicals,"
Journal of Food and Drug Analysis: Vol. 20
, Article 75.
Available at: https://doi.org/10.38212/2224-6614.2141