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Article Title

Common commercial immunoassay for workplace drug urinalysis - Principle, cross-reactivity and interference

Authors

R.H. Liu

Abstract

The underlying principles of the commonly used immunoassay, enzyme immunoassay, fluorescence polarization immunoassay, and 'particle' immunoassay are outlined. Cross-reacting characteristics of these immunoassays as reported by the manufacturers and independent laboratories are tabulated. This information shows that commercial immunoassay kits for drug categories that are included in workplace drug urinalysis programs are generally more specific than those kits that are for clinical use only. Furthermore, recently manufactured immunoassay kits targeted for use in workplace drug urinalysis programs are more specific than those manufactures earlier. Reported effects of adulterants, such as salt, cleaning agents, etc., on commonly used immunoassays are summarzied. Without more comprehensive and systematic studies, it is difficult to make general statements concerning the superiority of one methodology over the others. It is clear, however, that cannabinoid assays are most susceptible to the influence of adulterants.

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