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Article Title

The effect of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. extract on cadmium-induced toxicity in mice

Abstract

The present study analyzed the effects of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. ethanol extract on long-term (6-week) intoxication induced by intraperitoneal injections of 0.05 LD 50 of cadmium chloride solution. The experiments were performed with white laboratory mice. Two groups of mice were injected with ethanol extract of E. senticosus: 0.05 LD 50 and 0.10 LD 50. Cadmium concentrations were investigated in blood, kidney, liver, spleen, heart, and skeletal muscle by atomic absorption spectroscopy. Long-term injections of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. ethanol extract combined with CdCl 2 led to significant increase of cadmium concentrations in the spleen, skeletal muscle, blood, kidney and liver of experimental mice. E. senticosus also decreased the mitotic activity of liver cells induced by cadmium.

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