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Article Title

Mesaconitine plays the major role in the antinociceptive and anti-inflammatory activities of Radix Aconiti Carmichaeli (Chuan Wu)

Abstract

This study investigated the antinociceptive and anti-inflammatory activities of the aqueous extracts of Radix Aconiti Carmichaeli (Chuan Wu) by oral gavage in mice. Carrageenan-induced paw edema served as an acute inflammation model. The acetic acid-induced writhing test and formalin-induced nociceptive responses in the early and late phases were used to assess the analgesic activity. The contents of Aconitum alkaloids were analyzed by high-performance liquid chromatography. The order of concentration of aconitine-type alkaloids in Radix Aconiti Carmichaeli was mesaconitine > aconitine > hypaconitine. Radix Aconiti Carmichaeli water extract at the dosage of 60 mg/kg not only effectively inhibited carrageenan-induced paw edema, but also significantly attenuated the abdominal constriction induced by an intraperitoneal injection of acetic acid, as well as the late phase of pain response caused by a hindpaw injection of formalin. Mesaconitine and aconitine are effective in decreasing the pain sensation elicited by acetic acid. The aqueous extracts of Radix Aconiti Carmichaeli exhibits antinociceptive activity and anti-inflammatory effect probably due to the presence of high content of mesaconitine.

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