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Article Title

Physicochemical characterizations of ostholehydroxypropyl-β- cyclodextrin inclusion complexes with high-pressure homogenization method

Abstract

The purpose of this research was to evaluate the inclusion complex composed of osthole and hydroxypropyl-β-cyclodextrin (HP-β-CD) by using two preparative techniques, neutralization and high-pressure homogenization (HPH) method. The solid complexes were characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), particle size determination, and dissolution test. The DSC diagrams indicated that the solid complex from the HPH method led to more complete complexation than that of physical mixture and neutralization method. The formation of inclusion complex between drug and cyclodextrin (CD) was verified by FTIR analysis. The smallest mean particle size of solid complex was acquired from the HPH method. The results proved that the rate of drug release for the inclusion complex obtained from the HPH method was much faster than those of neutralization, physical mixture, HP-β-CD and osthole alone.

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