Abstract
The carotenoid extract from Dunaliella salina was identified and quantitated. The effects against cadmium (Cd)-induced hepatotoxicity and transforming growth factor β1 (TGF-β1)-induced activation of hepatic stellate cells (HSCs) were evaluated. All-trans-β-carotene (474.82 mg/g extract) and 9- or 9′-cis-β-carotene (425.64 mg/g extract) were major carotenoids in the extract, accounting for 90.30% of total carotenoids (997.17 mg/g extract). Other carotenoids were all-trans-lutein (22.77 mg/g extract), all-trans-zeaxan-thin (39.26 mg/g extract), 13- or 13′-cis-β-carotene (17.18 mg/g extract), all-trans-α-carotene (9.26 mg/g extract) and 9- or 9′-cis-α-carotene (8.24 mg/g extract). The algal extract had a higher effect (p < 0.05) than all-trans-β-carotene in the reduction of cytotoxicity for CdCl2-treated Clone 9 cells and expression of smooth muscle α-actin (αSMA) for TGF-β1-treated HSC-T6 cells. These effects were shown to be concentration-dependent.
Recommended Citation
Lin, J.-T.; Lee, Y.-C.; Hu, C.-C.; Shen, Y.-C.; Lu, F.-J.; and Yang, D.-J.
(2010)
"Evaluation of carotenoid extract from Dunaliella salina against cadmium-induced cytotoxicity and transforming growth factor β1 induced expression of smooth muscle α-actin with rat liver cell lines,"
Journal of Food and Drug Analysis: Vol. 18
:
Iss.
5
, Article 8.
Available at: https://doi.org/10.38212/2224-6614.2279
