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Article Title

Short term monitor of photodegradation processes in ranitidine hydrochloride observed by FTIR and ATR-FTIR

Abstract

The effects of degradation of ranitidine hydrochloride exposed to UVB radiation (λ = 310 nm) and oxygen in a weathering chamber were studied by Fourier Transform Infrared spectroscopy (FTIR) and Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR). ATR-FTIR profile indicated that the degradation was spatially heterogeneous. Significant amounts of photoproducts were detected only in a directly irradiated layer. Major damage/change was reflected in the appearance of broad, extended group of signals near the wavenumber 3600-3200 cm-1 or/and 3500-3400 cm -1. We examined whether FTIR-ATR technique is a great tool to observe the simplest and the first changes on the surface of a substance in powder.

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