Article Title

Effect of different organized media on ion-selective electrode (ISE) determination of propranolol in pharmaceutical dosage forms


This study examined the effect of different organized media such as β-cyclodextrin and micelle surfactants, either anionic (sodium dodecyl sulphate), cationic (cetrimide) or non-ionic (tween-20 and tween-80), on the potentiometric properties of propranolol polyvinyl chloride selective electrode based on tetraphenyl borate (PRO-TPB) ion-exchanger as an electroactive material. It was found that the Nernstian slope for propranolol over the concentration range of 1 × 10-5 to 10-2 M was unaffected by non ionic surfactant, whereas cationic surfactant significantly decreased the Nernstian slope. However, anionic surfactant significantly increased the Nernstian slope. The electrode basic analytical parameters such as measurement range, slope characteristics, detection limit, response time, and selectivity coefficients in relation to some inorganic cations, sugars, amino acids and some β-blockers were investigated in presence or absence of organized media. Electrode was used for the potentiometric determination of propranolol in pharmaceutical preparations with and without organised compounds. The results were consistent with those obtained using a reference method.

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