Phenylpropanolamine (PPA) hydrochloride used as nasal decongestant agent was determined by second derivative spectrophotometry after derivatization with 2-hydroxynaphthaldehyde. The absorbance was measured between minimum-maximum of 386 nm-392 nm. The linear calibration range was obtained within 0.5∼2.0 μg/mL. The method was applied for the determination of phenylpropanolamine from pharmaceutical preparations Tavegyl-D and Sinutab with coefficient of variation of 0.8∼1.6%. Paracetamol present together with phenylpropanolamine could also be determined by spectrophotometry in aqueous phase after extraction of PPA in chloroform.
Khuhawar, M.Y.; Rind, F.M.A.; and Rajper, A.
"Determination of phenylpropanolamine in pharmaceutical preparations by second derivative spectrophotometry,"
Journal of Food and Drug Analysis: Vol. 13
, Article 9.
Available at: https://doi.org/10.38212/2224-6614.2567