Article Title

Differential electrolytic potentiometric titration of vitamin C in pharmaceutical preparations


The application of direct current differential electrolytic potentiometry for the aqueous titration of vitamin C has been investigated. The reaction of vitamin C with Ce (IV) is fast enough to permit its direct titration in 0.09 M sulfuric acid media. Cerium ammonium sulfate was used as a titrant and a couple of platinum electrodes as an indicating system. Titration curve shapes obtained are almost symmetrical with sharp peaks. The optimum current density was found to be 0.65 μA cm-2. The procedure was applied successfully to the determination of vitamin C in commercial tablets, capsules as well as in juice in the concentrations of 0.02∼10 ppm. The results of this study were favorably compared statistically with those obtained with official methods.

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