A method for simultaneous quantitation of caffeine, ethoxybenzamide and propyphenazone is described. The method was based on reversed-phase high-pressure liquid chromatography with a mobile phase of methanol-acetonitrile-3% aqueous acetic acid solution (24 : 16 : 60, v/v). The compounds were well separated from each other by the procedure, using salicylamide as internal standard. The method gave excellent results and provided a simple, rapid and accurate method for separation and quantitation of synthetic mixtures and commercial products.
Lee, An-Rong; Sung, Kuang-Sen; and Huang, Wen-Hsin
"Simultaneous Quantitation of Caffeine, Ethoxybenzamide and Propyphenazone in Oral Analgesic Tablets by High-Pressure Liquid Chromatography,"
Journal of Food and Drug Analysis: Vol. 1
, Article 5.
Available at: https://doi.org/10.38212/2224-6614.3072