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Article Title

Application of HPLC Method for Quality Control of Cefadroxil

Abstract

Our previous study has shown that HPLC method is a suitable substitute for the microbiological method for potency assays and stability studies of cefadroxil preparations. The samples were analysed on u--Bondapak C18 column with a mobile phase consisting of acetonitrile and phosphate buffer. The assay was also applied successfully to five different commercial brands and proved to be free of interference from excipients normally used informulations. The contents of unifomity and dissolution rates in different brands were performed. The results have shown that this analytical method could be utilized readily for routine quality control of cefadroxil pharmaceuticals, since it offers a simple system and short analytical time coupled with reproducibility and accuracy.

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