Evaluating the Potential of Cajanus cajan (L.) Millsp. Root to Improve Atopic Dermatitis with Different Anti-inflammatory Models and Active Compounds

Authors

• Shu-Er Yang, Department of Beauty Science and Master Program of Beauty Science and Technology, Chienkuo Technology University, Changhua, Taiwan
• Xiang-Ming Cai, Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Taiwan
• Yu-Wen Chu, Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan (R.O.C);
• Jen-Chieh Tsai, School of Pharmacy, China Medical University, Taichung, Taiwan No. 100, Section 1, Jingmao Road, Beitun District, Taichung City 406040Affiliation 1
• Mey-Fann Lee, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan (R.O.C);
• Tuzz-Ying Song, Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, TaiwanFollow

Keywords

Atopic dermatitis; Cajanus cajan (L.) Millsp., methicillin-resistant staphylococcus aureus (MRSA); Anti-inflammatory

Abstract

Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent bacterial infections that cause pruritus, erythema, xerosis and thickening. Cajanus cajan root extract prepared with 95% ethanol (EECR95) has been shown to possess antioxidant, anti-inflammatory, and antibacterial properties in previous studies. This study aimed to evaluate EECR95’s ability to improve AD by inhibiting methicillin-resistant Staphylococcus aureus (MRSA) growth and reducing inflammation. This study found EECR95 effectively inhibits MRSA growth (IC₅₀ = 103.74 μg/mL) and reduces pro-inflammatory cytokine production in an MRSA-keratinocyte-macrophage model. LC/MS/MS analysis revealed the presence of active compounds- flavonoids, isoflavones, and flavonoid glycosides, highlighting EECR95's potential in improving atopic dermatitis in vitro.

Abstract Image

Recommended Citation

Yang, Shu-Er; Cai, Xiang-Ming; Chu, Yu-Wen; Tsai, Jen-Chieh; Lee, Mey-Fann; and Song, Tuzz-Ying (2026) "Evaluating the Potential of Cajanus cajan (L.) Millsp. Root to Improve Atopic Dermatitis with Different Anti-inflammatory Models and Active Compounds," Journal of Food and Drug Analysis: Vol. 34 : Iss. 3 , Article 12.
Available at: https://doi.org/10.38212/2224-6614.3591

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