Abstract
The study combined UHPLC-Q-Orbitrap-MS analysis with authentic standards, to create a novel strategy for isomers recognition and putative identification. Through the strategy, anti-Covid-19 Jinhua Qinggan Granule was found to comprise 28 isomers and 45 potential anti-Covid-19 constituents. The detection of three constituents (Danshensu, cryptotanshin, and tanshinone IIA) suggests Danshen as confidential additive. Based on this, 6 constituents are recommended as quality-marker candidates, including chlorogenic acid, acteoside, peimisine, baicalein, licoricesaponin H2, and tanshinone IIA. Obviously, the study can not only help the public to really understand the Granule's formula and chemistry, but also facilitate its Pharmacopoeia collection in future.
Recommended Citation
Zeng, Jingyuan; Li, Xican; Cai, Rongxin; Li, Chunhou; and Chen, Shaoman
(2023)
"Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation,"
Journal of Food and Drug Analysis: Vol. 31
:
Iss.
3
, Article 11.
Available at: https://doi.org/10.38212/2224-6614.3466
Research highlights_11.pdf (106 kB)
Supporting Information_Article 11 (MS 3466).pdf (6350 kB)
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